Convective washout reduces the antidiarrheal efficacy of enterocyte surface–targeted antisecretory drugs
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چکیده
منابع مشابه
Convective washout reduces the antidiarrheal efficacy of enterocyte surface–targeted antisecretory drugs
Secretory diarrheas such as cholera are a major cause of morbidity and mortality in developing countries. We previously introduced the concept of antisecretory therapy for diarrhea using chloride channel inhibitors targeting the cystic fibrosis transmembrane conductance regulator channel pore on the extracellular surface of enterocytes. However, a concern with this strategy is that rapid fluid ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2013
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201210885